People

The members of Clotwork are dedicated to develop new strategies in coagulation management in bleeding patients in the field of emergency medicine, perioperative medicine and critical care medicine that will decrease blood transfusions, thereby improving patient safety and decreasing healthcare costs.


Dietmar Fries - Board member

A. Univ. Prof. Dr.
Department of General and Surgical Critical Care Medicine, Medical University Innsbruck/ Austria

Assoc. Professor Dr. Dietmar Fries graduated from the University of Innsbruck in 1989. He underwent his residency training in anesthesia, intensive care and emergency medicine from 1999 till 2005. He received his associate professorship in September 2006. He is currently a senior staff physician in the Department for General and Surgical Intensive Care Medicine of the Innsbruck Medical University/Austria. Assoc. Professor Dr. Fries is an active member in several European Societies.

Namely he is head of the “Coagulation Task Force” in the Austrian Society for Anesthesiology, Intensive and Resuscitation (ÖGARI), member of the task force for “Haemotherapy and Shock” in the German Interdisciplinary Society for Intensive Care Medicine (DIVI), member of the “task force for severe bleeding management” in the European Society of Intensive Care Medicine (ESA) and also a member of the Society for Thrombosis and Haemostasis (GTH) and of the European Society of Intensive Care Medicine (ESICM). Associate Professor Fries main research interest is in the area of volume replacement and transfusion in massive bleeding and critically ill patients. An Austrian born in Cologne, Germany. He is married with his wife Astrid, an architect; he has a 10 year old son and lives with his family in Innsbruck, Austria.

contact information 

E-mail: 
Dietmar [dot] Friesati-med [dot] ac [dot] at
Address: 

Department of General and Surgical Critical Care Medicine

Medical University Innsbruck
Anichstraße 35
A-6020 Innsbruck

Petra Innerhofer - Board member

Univ.-Doz. Dr.
Head of Anesthesiology for the Department of Pediatrics, Orthopedics, MRI and Plastic Surgery
Medical University Innsbruck/ Austria

EDUCATION
1975 - 1981 Innsbruck University, Innsbruck, Austria:Studied Human Medicine at the Faculty of Medicine


1981            Doctoral degree (Dr. med. univ., Doctor Medicinae Universae) in Human Medicine received from Innsbruck        
                    University.

PROFESSIONAL CAREER
1983 - 1986 Innsbruck University Hospital: Medical rotation
1986 - 1990 Innsbruck University Hospital: Residency in Anesthesiology and Critical Care Medicine
1990            Emergency Physician Diploma
 1990           Specialization in Anesthesiology and Critical Care Medicine recognized
                    by the Austrian Medical Association
1993            Innsbruck University Hospital: Assistant Head of Anesthesiology for
                    the Department of Pediatrics, Orthopedics and MRI
1993/94       University of Innsbruck and Training Center West, Innsbruck, Austria:
                    International University Course in Hospital Management
1997/98      Trained in transesophageal echocardiography (TEE) in Innsbruck
2002            Innsbruck Medical University: Venia docendi granted in Anesthesiology and Critical Care Medicine
                    (Venia docendi thesis: „Immunological Side-Effects of Allogeneic and Autologous Blood
                    Transfusions“)
2005            Head of Anesthesiology for the Department of Pediatrics, Orthopedics, MRI and Plastic Surgery

RESEARCH FOCUS
1. Perioperative transfusion therapy
2. Regional anesthesia in pediatric anesthesiology
3. Volume therapy, management of massive blood loss
4. Perioperative coagulation management, traveler's thrombosis

MEMBERSHIPS IN PROFESSIONAL ORGANISATIONS
Austrian Society for Anesthesiological and General Intensive Care Medicine (ÖGAAIM)
Austrian Study Group for Anesthesiology and Intensive Care Medicine in Childhood (AIKI)
Austrian Society for Anesthesia, Resuscitation and Intensive Care Medicine (ÖGARI, member of the Study Group for Perioperative Coagulation)
Austrian Society for Autologous Blood Transfusion
Network for Advancement of Transfusion Alternatives (NATA)
Head of the Innsbruck Research Group “Perioperative Coagulation Management”
German and International Society on Thrombosis and Haemostasis (GTH, ISTH)
European Society of Anaesthesiologists (ESA)

Date and Place of Birth: March 3, 1957, Innsbruck, Austria
Nationality: Austrian
Marital Status: Married

contact information 

E-mail: 
Petra [dot] Innerhoferati-med [dot] ac [dot] at
Phone: 
+43 512 504 80407
Address: 
Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University , Innsbruck , Austria

Corinna Velik-Salchner - Board member

Priv.-Doz. Dr.
Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck

contact information 

Address: 


Barbara Friesenecker

ao. Univ.-Prof. Dr. med.
Department of General and Surgical Critical Care Medicine, Medical University Innsbruck/ Austria

Education
1968-1972 Primary school and high school in Munich and Königstein/Frankfurt
11.12.1980 Graduation from Highschool WS 1981- SS 1991 Medical school of the 'Leopold-Franzens'-University, Innsbruck
23.3.1991 Graduation from Medical School
6/1991 - 10/1994 Stipend at the University Hospital for Anesthesiology and General Intensive Care Medicine, Medical University Innsbruck (Director: Prof. Dr. H. Benzer) as member of the research group 'Oxygen Transport' (Head: Prof. Dr. W. Hasibeder)


6/1992 - 10/1994: Visiting Research Bioengineer at the Department of Bioengineering, UCSD, (University of California, San Diego); Microcirculation laboratory (Head: Prof. Marcos Intaglietta, PhD)
11/1994 Start of residency training at the University Hospital for Anesthesiology and General Intensive Care Medicine, Medical University Innsbruck (Director: Prof. Dr. H. Benzer)
30.11.2000 Attending in Anesthesiology and Intensiv Care Medizin
24.1.2001 Diploma in Emergency Medicine
from 3/2001 Attending at the University Hospital for General and Surgical Intensive Care Medicine, Medical University of Innsbruck, Director: Prof. Dr. N. Mutz
1.3.2007 Professorship in Anesthesiology and General Intensive Care Medicine Research

Exchange Activities
1995 - 2003 Visiting Research Bioengineer at the Department of Applied Mechanics and Bioengineering, UCSD (Head: Prof. M. Intaglietta, PhD)

Stipends and Research Grants
1992 Foreign Exchange Stipend of the Leopold - Franzens - University, Innsbruck
1992 Stipend of the Landesgedächtnisstiftung, Tirol
1993 Stipend of the Landesgedächtnisstiftung, Tirol
1993 Young Investigators Award (Blood Substitute Research)
1993 - 1994 Erwin-Schrödinger-Stipend of the Austrian Science Foundation
1995 Innovationspreis of the Tiroler Sparkasse
1995 Supported by the Jubiläumsfonds of the Austrian National Bank
1996 Supported by an außerordentliche Dotation of the Leopold - Franzens - University, Innsbruck
2002 Supported by the Medizinischen Forschungsfonds Tirol (MFF Tirol)

Main Research Interest
Microcirculation: Micro-Hemodynamics and Oxygen Transport
Blood Substitutes
Clotting system

Reviewer
BMC Emergency Medicine
Critical Care Forum
British Journal of Anesthesia (BJA-2009-00647-HH090)
SNF (Swiss National Science Foundation; 32003B_127619)

contact information 

E-mail: 
barbara [dot] frieseneckerati-med [dot] ac [dot] at
Phone: 
(+43) 0512/504-80395
Address: 

Department of General and Surgical Critical Care Medicine
Medical University Innsbruck
Anichstraße 35
A-6020 Innsbruck

Thorsten Haas

Associate Professor
Department of Paediatric Anaesthesia, University Children's Hospital Zurich, Switzerland

Thorsten Haas is an anaesthesiologist who specializes in paediatric anaesthesia. He is senior staff anaesthetist at University Children's Hospital Zurich, Switzerland.


Dr. Haas grew up in Germany graduated from Johannes Gutenberg University in Mainz and completed his anaesthesiology residency in Germany and Austria. He is a certified clinical risk manager and has gained qualification as chief emergency physician in Tirol, Austria.

The research interests of Dr. Haas include point-of-care coagulation testing, the influence of colloids on hemostasis, and perioperative coagulation management with special focus on paediatric major surgeries. Recent publications include a comparison of several coagulation test devices with the ROTEM®, perioperative coagulation management of children, the influence of crystalloids and colloids on hemostasis, the use of fibrinogen for treating dilutional coagulopathy. At present, he is sponsor of a phase IV trial that compares two different laboratory thresholds for the use of fibrinogen during major paediatric surgery (FibPaed study). He is a peer reviewer for multiple major anaesthesia journals. From 2007 to 2009 Dr. Haas has worked as medical director in clinical research & development at CSL Behring Marburg, Germany. During this time he was responsible for medical/therapeutical concepts of phase I-IV studies, collaboration with key opinion leaders worldwide, and medical expert for contacts to authorities (FDA, EMEA, PEI).
Dr. Haas is currently member of the European Society of Anaesthesiology (ESA) Subgroup for Perioperative Coagulation Management.

He lives in Zurich, Switzerland and Innsbruck, Austria together with his wife Claudia and his two children Jennifer and Lukas.

contact information 

E-mail: 
Thorsten [dot] Haasatkispi [dot] uzh [dot] ch
Phone: 
Tel: +41 44 266 8152
Homepage: 
Address: 

Priv. Doz. Dr. med. Thorsten Haas

Department of Paediatric Anaesthesia
University Children's Hospital Zurich
Steinwiesstrasse 75
8032 Zürich
Switzerland

Martin Hermann

Dr. Mag. rer. nat.
Department of Anesthesia and Critical Care Medicine, Medical University Innsbruck, Austria

Dr. Hermann graduated from the University of Salzburg in 1991 where he studied Biology/Genetics. He worked at the Biomedical Aging Institute of the Austrian Academy of Sciences, the Biochemistry Laboratory of the Women´s Hospital, the Neurobiochemistry Department, and the KMT-Laboratory of the Surgical Department of the Medical University in Innsbruck. Currently he runs the optical imaging facility of the Department of Anesthesia and Critical Care Medicine, Medical University Innsbruck Austria.

His main research interest is the confocal imaging of living cells and tissues.



contact information 

E-mail: 
Martin [dot] Hermannatuki [dot] at
Phone: 
(+43) 0512/504-27795
Address: 

Department of Anesthesia and Critical Care Medicine

Medical University
Innrain 66
A-6020 Innsbruck

Wenjun Zhou Martini

Ph.D.
Tenure Research Physiologist, U.S. Army Institute of Surgical Research

EDUCATION
1984, Chemical Engineering, B.S. -Zhejiang Institute of Technology, Hangzhou, China
1987, Chemical Engineering, M.S. -Zhejiang University, Hangzhou, China
1998, Nutrition and Physiology, Ph.D. -University of Texas Medical Branch, Galveston, TX, USA

ORGANIZATION
American Physiological Society and SHOCK Society

RESEARCH AND PROFESSIONAL EXPERIENCE
1/2003- Present Research Physiologist, U.S. Army Institute of Surgical Research, Ft. Sam Houston, TX 78234
6/2001-1/2003 Post-doc fellow, Dept. of Physiology and Nutrition, Case Western Reserve University, Cleveland, OH 44122
1/1999-5/2001 Post-doc fellow, Metabolism unit, Shriners Burns Hospital, Galveston, TX 77550
1/1995-12/1998 Graduate student, the University of Texas Medical Branch, Galveston, TX 77555

HONORS
1. Graduate student Research Award from American Society for Nutritional Science, in recognition of an outstanding paper of Original Research, 1998.
2. The Caroline tum Sudden/ Frances A. Hellebrandt Professional Opportunity Award from the American Physiology Society for research in “Lung Surfactant Kinetics in Conscious Pigs”, 1998
3. The Caroline tum Sudden/ Frances A. Hellebrandt Professional Opportunity Award from the American Physiology Society for research in “Dietary effects on Surfactant Composition and Pulmonary Function”, 1999
4. N.I.H. (HL-007653), Research Fellowship
5. Invited speaker of “Alterations in Coagulation Process Induced by Acidosis, Hypothermia, and Hemorrhage”. Invited speech by the Defense Research and Development of Canada, Toronto, 2003.
6. The Best Manuscript award at the17th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2004.
7. Invited moderator of Scientific Session III & IV Alexander Competition at 18th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2005.
8. The Best Manuscript award at the19th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2006.
9. Invited moderator of Scientific Session III & IV Alexander Competition at 20th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2007.
10. Invited Chair of Coagulation Management session at the 3rd International Coagulation Course- Management of peri-opreative bleeding complications, Vienna, Austria, April 11-12, 2008
11. Invited plenary speaker at the Plenary session of “Multiple Injury and Coagulation” at the International SHOCK Congress, Cologne, Germany, 28 June – 2 July, 2008
12. Invited speaker at the international meeting of “Epidemiology, Mechanisms, Diagnosis and treatment of early coagulopathy following traumatic injury: Current state of Art”, Chicago, USA, 11-13-July, 2008.
13. Invited moderator at the 8th World Congress on Trauma, Shock, Inflammation, and Sepsis 2010, March 9-13, Munich, Germany.
14. Invited speaker at the session of “Coagulation Function and Resuscitation after Hemorrhage” at the 8th World Congress on Trauma, Shock, Inflammation, and Sepsis 2010, March 9-13, Munich, Germany.
15. Invited discussant of the Trans-Agency Coagulopathy in Trauma workshop by National Institute of Health, April 5-6, 2010, Bethesda, MD.
16. Editorial consultant for American College of Physicians, Physician’s Information and Education Resources, since 2008 to present.

PUBLICATIONS
1) Review articles:
1. Martini WZ. Fibrinogen and Trauma. Review article, MEDIMOND International Proceedings, 2008; 1-5.
2. Martini WZ. Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability. Review Article. J Trauma 2009 July, 67(1):202-8; discussion and editorial 208-9.
3. Martini WZ. Fibrinogen metabolic responses to trauma. Review Article. Scand J Trauma Resusc Emerg Med. 2009 Jan 13; 17(1):2-7.
4. Dietmar F and Martini WZ. The role of fibrinogen in trauma induced coagulopathy. Review article, British Journal of Anaesthesia 2010, in press.

2) Original papers:
5. Martini WZ, Chinkes DL, Barrow RE, Murphey ED, and Wolfe RR. Lung Surfactant Kinetics in Conscious Pigs. Am J of Physiol. 277: E187-95, 1999.
6. Martini WZ, Irtun O, Chinkes DL, Barrow RE, and Wolfe RR. Glucose effects on lung surfactant kinetics in conscious pigs. Am. J. Physiol. 279:E920-926, 2000.
7. Wolfe RR and Martini WZ. Changes in intermediary metabolism in severe surgical illness. World Journal of Surgery. 24:639-647, 2000.
8. Martini WZ, Irtun O, Chinkes DL, Barrow RE, and Wolfe RR. Surfactant phosphatidylcholine in thermally injured pigs. Critical Care Medicine. 29:1417-1422, 2001.
9. Irtun O, Martini WZ, Ozkan O, and Wolfe RR. Caval backflow – a potential problem during blood sampling from the hepatic vein. Metabolism. 50:189-193, 2001.
10. Martini WZ, Irtun O, Chinkes DL, Rasmussen B, Traber DL, and Wolfe RR. Alteration of Hepatic Fatty acid Metabolism after burn injury in Pigs. Journal of Parenteral and Enteral Nutrition. 25:310-316, 2001.
11. Wolfe RR, Martini WZ, Irtun O, Hawkins HK, and Barrow RE. Dietary fat composition alters pulmonary function in pigs. Nutrition. 18:647-653, 2002.
12. Kasumov T, Martini WZ, Reszko AE, Bian F, Piece BA, David F, Roe CR, and Brunengraber H. Assay of the concentration and 13C isotopic enrichment of propionyl-CoA, methylmalonyl-CoA, and Succinyl-CoA by Gas Chromatography- Mass Spectrometry. Analytical Biochemistry. 305:90-96, 2002.
13. Martini WZ, Stanley WC, Huang H, Rosier CD, Hoppel CL, and Brunengraber H. Quantitative assessment of anaplerosis of propionate in pig heart in vivo. AJP, 284: E351-356, 2003.
14. Martini WZ, Chinkes DL, and Wolfe RR. Quantification of DNA synthesis from different pathways in cultured fibroblasts and myocytes. Metabolism 2004, 53:128-133.
15. Martini WZ, Chinkes DL, and Wolfe RR. The intracellular free amino acid pool represents precursor enrichment for protein synthesis in cultured fibroblasts and myocytes. Journal of Nutrition. 2004, 134: 1546-1550.
16. Zhang, XJ, Chinkes DL, Wu Z, Martini WZ, and Wolfe RR. Measurements of DNA and protein metabolism in intact skin. Journal of Nutrition. 2004, 134: 2401-2406.
17. Chandler MP, Kerner J, Huang H, Vasquez E, Reszko A, Martini WZ, Brunengraber H, Hoppel CL, Imai M, Rastogi S, Sabbah HN, and Stanley WC. Moderate Severity Heart Failure Does Not Involve a Down-Regulation of Myocardial Fatty Acid Oxidation. AJP: Heart and Circulatory Physiology, 2004, 287:H1538-1543.
18. Martini WZ, Pusateri AE, Uscilowicz JM, Delgado AV, and Holcomb JB. Independent Contributions of Hypothermia and acidosis to Coagulopathy in Swine. Journal of Trauma. 2005, 58:1002-1010.
19. Martini WZ, Chinkes DL, Pusateri AE, Holcomb JB, Yu YM, Zhang XJ, and Wolfe RR. Acute Changes in Fibrinogen Metabolism and Coagulation after Hemorrhage in Pigs. Am J of Physiol 2005, 289: E930-934.
20. Okere IC, McElfresh TA, Brunengraber DZ, Martini WZ, Sterk J, Huang H, Chandler MP, Brunengraber H, and Stanley WC. Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia/reperfusion. J Appl Physiol 2005 Sep 1 (Epub ahead of print)
21. Martini WZ, Dubick MA, Pusateri AE, Park MS, Ryan KL, Holcomb JB. Does bicarbonate correct coagulation function impaired by acidosis in swine? J Trauma 2006, 61:99-106.
22. Martini WZ, Chinkes DL, Sondeen J, and Dubick MA. Effects of hemorrhage and Lactated Ringer’s resuscitation on coagulation and fibrinogen metabolism in swine. SHOCK 2006, 26:396-401.
23. Martini WZ. Effects of hypothermia on fibrinogen metabolism and coagulation function. Metabolism 2007, 56:214-221.
24. Martini WZ, Dubick MA, Wade CE, and Holcomb JB. Evaluation of tris-hydroxymethylaminomethane (THAM) on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med. 2007, June, 35 (6): 1568-74.
25. Martini WZ and Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and degradation in pigs. Ann Surg. 2007, Nov; 246:831-835.
26. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008 Feb; 64(2 Suppl):S79-S85. Discussion S 85.
27. Park MS, Salinas J, Wade CE, Wang JJ, Martini WZ, Pusateri AE, Merrill GA, Chung KK, Wolf SE, Holcomb JB. Combining Early Coagulation and Inflammatory Status Improves Prediction of Mortality in Burned and Nonburned Trauma Patients. J Trauma. 2008 Feb;64(2 Suppl):S188-S194.
28. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB TEG is Better than PT, aPTT and ACT in Detecting Clinically Relevant Clotting Abnormalities after Hypothermia, Hemorrhagic Shock and Resuscitation in Pigs. J Trauma, 2008;65:535-543.
29. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Wang JJ, Wolf SE, Mann KG, Holcomb JB. Thromboelastography is superior to PT/PTT for the assessment of hypercoagulability and fibrinolysis after injury in burned vs. trauma patients. J Trauma. 2009 Aug, 67:266-75; discussion 275-6.
30. Martini WZ, Wolf SE, Chinkes DL, Chung KK, Dubick MA, Blackbourne L, Yu YM. Enhanced albumin synthesis in severely burned adults. SHOCK, 2010, Feb [Epub ahead of print]

contact information 

E-mail: 
wenjun [dot] martiniatamedd [dot] army [dot] mil
Phone: 
(210) 916-4573
Address: 

U.S. Army Institute of Surgical Research

3400 Rawley E. Chambers
ISR Building. 3611
Ft. Sam Houston, TX 78234

Judith Martini

M.D.
Resident at the Department of Anaesthesia and Intensive Care Medicine, Medical University Innsbruck, Austria

EDUCATION

Medical M.D. Leopold-Franzens University Innsbruck Austria, November 2003

CLINICAL EXPERIENCE

May 2008 – present: Resident at the Department of Anaesthesia and Intensive Care Medicine, Medical University Innsbruck,  Austria

September 2007 – April 2008: Resident at the Department of Cardiology, Medical University Innsbruck, Austria

June 2006 – August 2007: Resident at the Department for Anaesthesiology and Critical Care Medicine of the University Clinic Jena, Germany

RESEARCH EXPERIENCE

January 2004 – April 2006 Research fellow at the Department of Bioengineering, University of California San Diego, Microhemodynamics Laboratory, with focus on plasma expander and artificial blood substitutes.

November/December 2003: Research activity at the Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens University Innsbruck, Austria. Study title: “Effect of Fibrinogen-and Prothrombincomplex Concentrate on Dilutional Coagulopathy in Pigs.”

October 2002-October 2003: Dissertation at the Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens University Innsbruck, Austria. Title: “Vasoactive substances, vessel wall pO2 gradients and tissue oxygenation: Microcirculatory studies in the hamster skinfold window preparation.”

MAIN RESEARCH FOCUS

1. Visualization of thrombus formation in a hamster microcirculation model and correlation to in vitro coagulation tests

2. Effect of coagulation products on the microcirculation

contact information 

E-mail: 
Judith [dot] Martiniati-med [dot] ac [dot] at
Address: 

Department of Anesthesia and Intensiv Care Medicine, Medical University Innsbruck , Anichstr. 35, A – 6020 Innsbruck

Uri Martinowitz

MD, Director
National Hemophilia Center, The Chaim Sheba Medical Center

Elgar Oswald

Dr.
Assistant Medical Director at the Department of Anesthesia and Intensiv Care Medicine, Medical University Innsbruck
Head of Department of Pediatric Anaesthesia at the Medical University Innsbruck

contact information 

E-mail: 
elgar [dot] oswaldatuki [dot] at
Phone: 
+43 – 512 – 504 – 80420